Toxic Ingestion/Acute Iron (Fe) Ingestion

Ingestion of toxic substances by children.

EPIDEMIOLOGY • American Association of Poison Control Centers’ database reports ∼ 1 million exposures to poisonings each year in children < 6 years of age • Substances most available to children include those items in the home, such as cosmetics, cleaning products, analgesics, plants, cough medicine, foreign bodies, topical agents, pesticides, vitamins and hydrocarbons • Increased risk of death...

Uptake of iron and nitrilotriacetate (NTA) in rat liver and the toxic effect of Fe-NTA.

A previous study has shown that a single injection of ferric nitrilotriacetate (Fe-NTA) produces hepatic parenchymal iron loading in rats. The present paper reports on iron uptake by rat liver and iron toxicity in the liver after a single injection of Fe-NTA (7.5 mg Fe/kg B.W.). Iron uptake was examined with 59Fe-NTA and Fe-[14C]-NTA. Thirty percent of the injected 59Fe was incorporated in the ...

Shot ingestion in geese Seasonal ingestion of toxic and nontoxic shot by Canada geese

We used rates of ingested shot and elevated blood-lead levels (>0.18 ppm) to estimate the proportion of Canada geese (Branta canadensis) exposed to lead on 3 study areas in Manitoba, Minnesota, and Missouri. Lead exposure was prevalent on all areas and was common after the hunting season closed, when up to 15% of geese could have been exposed to lead shot. However, the proportion of steel shot ...

Ingestion of microcystins by Daphnia: Intestinal uptake and toxic effects

We investigated the intestinal uptake and adverse effects of microcystins ingested with Microcystis on Daphnia galeata. The gut structure, blood microcystin concentration, appearance, and movements of Daphnia fed Microcystis PCC 7806 or a microcystin-deficient PCC 7806 mutant were monitored over time. Microcystins were rapidly taken up from the digestive cavity into the blood. This process appa...

Toxic epidermal necrolysis following chlorpromazine ingestion complicated by SIADH.